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BCR/ABL and leukemia
A Butturini1, R B Arlinghaus, R P Gale
1Department of Pediatrics, University of Parma, Italy.
Leukemia Research
|June 1, 1996
Abstract:
This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of possible therapeutic implications of these data.