Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Legionnaires' disease: nickel levels

J R Chen, R B Francisco, T E Miller

Science (New York, N.Y.)

|May 20, 1977

Summary

This summary is machine-generated.

Nickel levels in lung tissue were nine times higher in deceased Legionnaires compared to controls. Lung tissue weight correlated with nickel concentration in victims, but not in control subjects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gynosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2024

Same author

Effect of phosphorus doping on the luminescence intensity of Si-NC in SiO/Si multilayers.

Optics express·2023

Same author

[Treatment and prognosis of head and neck rhabdomyosarcoma in children].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2023

Same author

[A case of primary epithelioid angiosarcoma of the tonsil in a patient with recurrent hepatocellular carcinoma with pulmonary metastasis].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2021

Same author

Correlation between the invasion mechanism of papillary thyroid carcinoma and expressions of NF-κB and the epithelial-mesenchymal transition-associated factors.

Journal of biological regulators and homeostatic agents·2021

Same author

Characterization of a hospital-based gastroenteritis outbreak caused by GII.6 norovirus in Jinshan, China.

Epidemiology and infection·2020

Area of Science:

Environmental Science
Toxicology
Pathology

Background:

Legionnaires disease is a severe form of pneumonia.
Environmental factors and heavy metal exposure are investigated for potential links to disease severity.

Purpose of the Study:

To investigate nickel concentrations in lung and kidney tissues of deceased Legionnaires disease victims.
To determine if nickel levels correlate with tissue weight in affected individuals.

Main Methods:

Analysis of nickel concentrations in lung and kidney tissues.
Comparison of tissue samples from nine deceased Legionnaires victims and control subjects.
Statistical analysis to assess correlation between nickel levels and tissue weights.

Main Results:

Related Experiment Videos

Average nickel concentrations in the lungs of Legionnaires victims were nine times higher than in controls.
A significant positive correlation was observed between nickel levels and lung specimen weights in Legionnaires victims.
No significant correlation between nickel levels and kidney tissue weight was found in either group.

Conclusions:

Elevated nickel concentrations in lung tissue may be associated with Legionnaires disease.
Lung tissue weight is a potential factor influencing nickel accumulation in Legionnaires victims.
Further research is warranted to understand the role of nickel in Legionnaires disease pathogenesis.