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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
HIV-associated respiratory diseases
1Department of Sexually Transmitted Diseases, University College London Medical School, UK.
Abstract:
The lungs of individuals infected with HIV are often affected by opportunistic infections and tumours; over two-thirds of patients have at least one respiratory episode during the course of their disease. Despite the availability of effective prophylaxis, infection with the fungus Pneumocystis carinii remains a common cause of respiratory disease. Bacterial infections, which occur more frequently in HIV-infected persons than in the general population, and tuberculosis are increasing causes of morbidity and mortality. Kaposi's sarcoma, the commonest HIV-associated malignancy, may affect the lungs in addition to the skin. Pulmonary involvement by non-Hodgkin lymphoma is common in those with disseminated disease.
Insights
Individuals with HIV frequently experience lung issues, including opportunistic infections like Pneumocystis pneumonia and bacterial infections. Tuberculosis and cancers such as Kaposi
Area of Science:
- Pulmonology
- Infectious Diseases
- Oncology
Background:
- Individuals with HIV often develop opportunistic infections and tumors affecting the lungs.
- Over two-thirds of HIV patients experience at least one respiratory episode.
- Pneumocystis pneumonia remains common despite prophylaxis.
Purpose of the Study:
- To review common pulmonary complications in individuals with HIV.
- To highlight the incidence and types of respiratory diseases in HIV patients.
Main Methods:
- Literature review of opportunistic infections, tumors, and respiratory diseases in HIV patients.
- Analysis of epidemiological data on pulmonary involvement in HIV.
Main Results:
- Pneumocystis pneumonia is a frequent respiratory illness in HIV patients.
- Bacterial infections and tuberculosis are increasing causes of morbidity and mortality.
- Kaposi's sarcoma and non-Hodgkin lymphoma commonly affect the lungs in HIV patients.
Conclusions:
- Pulmonary complications are a significant concern in HIV management.
- Early diagnosis and treatment of respiratory diseases are crucial for HIV patients.
- Comprehensive care should address both infectious and neoplastic lung conditions in HIV.
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