Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydralazine-induced constrictive pericarditis

C F Franssen1, M I el Gamal, R O Gans

  • 1Department of Medicine, Catharina Hospital, Eindhoven, Netherlands.

The Netherlands Journal of Medicine
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dutch guideline for the management of electrolyte disorders--2012 revision.

The Netherlands journal of medicine·2013
Same author

Renal abnormalities in a family with Alagille syndrome.

The Netherlands journal of medicine·2010
Same author

Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2009
Same author

Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.

Diabetologia·2009
Same author

Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient.

Optics express·2009
Same author

[Causes of otalgia from outside the ear].

Nederlands tijdschrift voor geneeskunde·2003
Same journal

A diagnostic tool for self-poisoned patients: Analysis of gastric content and lavage fluids.

The Netherlands journal of medicine·2020
Same journal

Answer to Photoquiz A bone disorder with skin lesions.

The Netherlands journal of medicine·2020
Same journal

A bone disorder with skin lesions.

The Netherlands journal of medicine·2020
Same journal

Answer to Photoquiz A fascinating liver abscess.

The Netherlands journal of medicine·2020
Same journal

A fascinating liver abscess.

The Netherlands journal of medicine·2020
Same journal

Answer to Photoquiz A polyposis syndrome.

The Netherlands journal of medicine·2020
See all related articles

Hydralazine can cause autoimmune syndromes, including rare late-onset constrictive pericarditis. This case highlights a delayed cardiac complication linked to hydralazine-induced autoimmune conditions.

Area of Science:

  • Cardiology
  • Rheumatology
  • Clinical Immunology

Background:

  • Hydralazine is a vasodilator used to treat hypertension.
  • Drug-induced autoimmune syndromes are known adverse effects of certain medications.
  • Constrictive pericarditis is a serious cardiac condition.

Observation:

  • A 59-year-old man developed constrictive pericarditis 17 months after hydralazine-induced autoimmune syndrome.
  • This represents a rare, late-onset complication of hydralazine therapy.
  • Ten years post-diagnosis, anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) were detected.

Findings:

  • The patient's constrictive pericarditis was linked to a prior hydralazine-induced autoimmune reaction.
  • The presence of MPO-ANCA antibodies suggests an autoimmune mechanism.

Related Experiment Videos

  • This case underscores the potential for delayed and unusual presentations of drug-induced autoimmunity.

    • Implications:

    • Clinicians should consider hydralazine as a potential cause of late-onset constrictive pericarditis.
    • Monitoring for autoimmune phenomena, even years after drug exposure, may be warranted.
    • Further research into the long-term autoimmune sequelae of hydralazine is needed.