[Phonophoretic permeation of procaine hydrochloride through an MDCK cell monolayer]

With the aid of permanent cultured MDCK (Madin Darby Canine Kidney) epithelial cell a model for investigations dealing with phonophoresis effects was developed. The permeation of procaine hydrochloride through cell monolayers was examined while applying therapeutical ultrasound simultaneously. It could be shown that this permeation follows Higuchi kinetics. A comparison of the velocity factors, using a continuous irradiation of 1.0 W/cm2, shows about a 4.8 fold increase. Single Ultrasound pulses, however, result in a short-time enhancement of the permeation. The conclusion can be drawn that extent and velocity of the permeation of the permeation of procaine hydrochloride through MDCK monolayer can be controlled by phonophoresis.