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[Inhalant abusers and psychiatric symptoms]

K Okudaira1, T Yabana, H Takahashi

  • 1Kanagawa Prefectural Center of Psychiatry, Serigaya Hospital, Japan.

Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica
|January 1, 1996
PubMed
Summary

Chronic psychiatric symptoms in inhalant abusers may stem from both substance abuse and genetic predisposition. This suggests a dual diagnosis model is crucial for understanding these complex cases.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Addiction Medicine

Background:

  • Differing international perspectives exist on the etiology of chronic psychiatric symptoms in drug abusers.
  • Japanese psychiatrists often attribute these symptoms to drug abuse, while foreign counterparts consider dual diagnoses of substance abuse and psychosis.

Observation:

  • A study examined 120 inhalant abusers, classifying them into psychosis, dependence, and abuse groups based on clinical presentation and duration of symptoms.
  • The psychosis group exhibited long-term psychiatric symptoms post-detoxification, while the dependence and abuse groups did not.

Findings:

  • Patients in the psychosis group showed a significantly higher incidence of schizophrenia in their family history (26.1%) compared to the dependence group (5.9%).
  • Chronic symptoms appeared an average of 5.7 years after initial inhalant abuse in the psychosis group.

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  • While poly-drug abuse was noted, it was not a statistically significant differentiator between psychosis and dependence groups.

    • Implications:

    • Results suggest that genetic factors, specifically a predisposition to psychosis, play a significant role in the development of chronic psychiatric symptoms alongside inhalant abuse.
    • The findings support a dual diagnosis approach for inhalant abusers presenting with persistent psychiatric issues, integrating genetic vulnerability assessments.