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Summary
Acute tumour lysis syndrome, a chemotherapy complication, causes dangerous electrolyte imbalances and kidney failure in dogs with lymphoma. Early detection and preventive strategies are crucial for managing this oncological emergency.
Area of Science:
- Veterinary Oncology
- Internal Medicine
- Nephrology
Background:
- Acute tumour lysis syndrome (ATLS) is a oncological emergency caused by the rapid breakdown of malignant cells.
- Chemotherapy-induced tumour lysis releases intracellular contents, leading to metabolic disturbances like hyperkalemia, hyperphosphatemia, and hyperuricemia.
- These metabolic derangements can precipitate calcium phosphate in renal tubules, causing acute kidney injury, hypocalcemia, and potentially fatal arrhythmias.