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Apolipoprotein E polymorphism and stroke in a population sample aged 75 years or more

H Basun1, E H Corder, Z Guo

  • 1Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden.

Stroke
|August 1, 1996
PubMed
Summary

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Apolipoprotein E (APOE) gene variants do not increase ischemic stroke risk in older adults. However, APOE may influence stroke survival and hemorrhagic stroke risk, with stroke contributing to cognitive impairment.

Area of Science:

  • Neuroscience
  • Genetics
  • Epidemiology

Background:

  • Apolipoprotein E (APOE) gene polymorphism is studied for its role in various neurological conditions.
  • The epsilon 4 allele is linked to cognitive impairment, while epsilon 2 is associated with longer survival in older adults with good cognition.

Purpose of the Study:

  • To investigate the association between apolipoprotein E (APOE) polymorphism and stroke risk in individuals aged 75 years and older.
  • To determine the proportion of cognitive impairment attributable to stroke in this elderly population.

Main Methods:

  • Genotyping of apolipoprotein E (APOE) in 1077 elderly subjects.
  • Comparison of stroke incidence across different APOE genotypes (epsilon 2/3, epsilon 3/3, epsilon 3/4).
  • Estimation of cognitive impairment proportion linked to stroke.

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Main Results:

  • No significant variation in stroke risk was observed across APOE polymorphisms (P = .82).
  • The epsilon 3/4 genotype was less frequent in stroke survivors.
  • Hemorrhagic stroke risk showed a tendency towards association with the epsilon 3/4 genotype.

Conclusions:

  • APOE polymorphism is not a risk factor for ischemic stroke in individuals aged 75 years and older.
  • APOE may influence post-stroke survival and hemorrhagic stroke risk.
  • Approximately 10% of cognitive impairment in this age group is attributable to stroke.