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Increased serum interleukin-10 level in Kawasaki disease
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Medical Journal
|April 1, 1996
Summary
Interleukin-10 (IL-10) levels are significantly elevated in acute Kawasaki disease (KD), indicating its role in immune response and inflammation. Levels decrease as KD resolves, returning to normal during convalescence.
Area of Science:
- Immunology
- Pediatric Rheumatology
Background:
- Kawasaki disease (KD) is an acute febrile illness affecting young children.
- The role of specific cytokines, like Interleukin-10 (IL-10), in KD pathogenesis is not fully understood.
Purpose of the Study:
- To investigate serum Interleukin-10 (IL-10) levels during different phases of Kawasaki disease (KD).
- To compare IL-10 levels in KD patients with those in febrile disease patients and healthy controls.
Main Methods:
- Serum samples were collected from KD patients during acute, subacute, and convalescent phases.
- Serum IL-10 levels were quantified using immunoassay techniques.
- Levels were compared between KD patients, patients with acute febrile disease, and age-matched controls.
Main Results:
- Markedly elevated serum IL-10 levels were observed in the acute phase of KD (122.0 pg/ml) compared to controls (3.7 pg/ml).
- Elevated IL-10 persisted in the subacute phase (16.7 pg/ml) and normalized in the convalescent phase (7.9 pg/ml).
- Patients with acute febrile disease showed increased IL-10 (34.4 pg/ml) but lower than in acute KD.
Conclusions:
- Elevated serum IL-10 in acute KD may modulate humoral immunity and reduce inflammation.
- IL-10 levels reflect disease activity and recovery in Kawasaki disease.