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Related Experiment Videos

The stomach in malnutrition

M Gracey, G J Cullity, Suharjono

    Archives of Disease in Childhood
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Malnourished children often have reduced gastric acid secretion and impaired gastric mucosal response. This may contribute to bacterial overgrowth and diarrhea in these vulnerable populations.

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    Area of Science:

    • Pediatric Gastroenterology
    • Nutritional Science
    • Gastrointestinal Physiology

    Background:

    • Malnutrition in infants and young children is a significant global health concern.
    • Gastrointestinal dysfunction is frequently observed in malnourished populations.
    • The specific impact of malnutrition on gastric acid secretion requires further elucidation.

    Purpose of the Study:

    • To investigate basal gastric acid output in malnourished children.
    • To assess the gastric mucosal response to pentagastrin stimulation in this cohort.
    • To explore the potential link between impaired gastric function and diarrheal diseases in malnutrition.

    Main Methods:

    • Measured basal gastric acid output in 14 infants and young children with malnutrition.

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  • Compared findings with 21 age-matched healthy controls.
  • Evaluated gastric mucosal response to pentagastrin stimulation.
  • Performed gastric biopsies in patients to assess for gastritis.

    • Main Results:

    • Reduced basal gastric acid output was observed in 9 out of 14 malnourished children.
    • Impaired gastric mucosal response to pentagastrin was noted in all studied patients.
    • Gastritis was present in 8 out of 9 patients who underwent biopsy.

    Conclusions:

    • Malnutrition is associated with significantly reduced gastric acid secretion in children.
    • Impaired gastric acid production and mucosal response may predispose malnourished children to bacterial overgrowth.
    • These gastrointestinal alterations likely contribute to the high incidence of diarrheal diseases in malnourished children.