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Evaluation of two dose individualisation methods for carboplatin
1GIBSA, Laboratoire de Pharmacologie, Institut Jean Godinot, Reims, France.
Anticancer Research
|July 1, 1996
Summary
Measuring total platinum (TP) in plasma offers a reliable alternative to ultrafiltered platinum (UP) for assessing carboplatin pharmacokinetics. This method accurately estimates TP clearance and other pharmacokinetic parameters in clinical practice.
Area of Science:
- Pharmacology
- Clinical Chemistry
- Nephrology
Background:
- Carboplatin pharmacokinetics are typically assessed using ultrafiltered platinum (UP) plasma concentrations.
- This UP method may be less reliable than measuring total platinum (TP) plasma concentrations.
Purpose of the Study:
- To evaluate the reliability of total platinum (TP) pharmacokinetics as an alternative to ultrafiltered platinum (UP) in clinical practice.
- To assess the accuracy of estimating TP clearance, Vc, and AUC using morphological and biological parameters and a Bayesian approach.
Main Methods:
- A reference group of 14 patients was used to establish correlations between TP clearance and creatinine clearance (Cockcroft and Gault).
- A validation group of 8 patients had TP clearance, Vc, and AUC estimated using morphological/biological parameters.
- A Bayesian approach with 2-3 plasma concentration measurements was used to estimate TP pharmacokinetic parameters.
Main Results:
- Estimated TP clearance in the validation group was 97.9 +/- 18% of the actual value.
- The Bayesian approach provided highly accurate TP pharmacokinetic parameter estimations, with clearance estimated at 99.9 +/- 2.7% of the actual value.
Conclusions:
- Total platinum (TP) pharmacokinetics can be reliably estimated as a clinical alternative to ultrafiltered platinum (UP).
- The Bayesian approach using limited plasma samples offers accurate TP pharmacokinetic assessment.