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Related Experiment Videos

Evaluation of two dose individualisation methods for carboplatin

B Desoize1, R Dufour, S Urien

  • 1GIBSA, Laboratoire de Pharmacologie, Institut Jean Godinot, Reims, France.

Anticancer Research
|July 1, 1996
PubMed
Summary

Measuring total platinum (TP) in plasma offers a reliable alternative to ultrafiltered platinum (UP) for assessing carboplatin pharmacokinetics. This method accurately estimates TP clearance and other pharmacokinetic parameters in clinical practice.

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Area of Science:

  • Pharmacology
  • Clinical Chemistry
  • Nephrology

Background:

  • Carboplatin pharmacokinetics are typically assessed using ultrafiltered platinum (UP) plasma concentrations.
  • This UP method may be less reliable than measuring total platinum (TP) plasma concentrations.

Purpose of the Study:

  • To evaluate the reliability of total platinum (TP) pharmacokinetics as an alternative to ultrafiltered platinum (UP) in clinical practice.
  • To assess the accuracy of estimating TP clearance, Vc, and AUC using morphological and biological parameters and a Bayesian approach.

Main Methods:

  • A reference group of 14 patients was used to establish correlations between TP clearance and creatinine clearance (Cockcroft and Gault).
  • A validation group of 8 patients had TP clearance, Vc, and AUC estimated using morphological/biological parameters.

Related Experiment Videos

  • A Bayesian approach with 2-3 plasma concentration measurements was used to estimate TP pharmacokinetic parameters.

    • Main Results:

    • Estimated TP clearance in the validation group was 97.9 +/- 18% of the actual value.
    • The Bayesian approach provided highly accurate TP pharmacokinetic parameter estimations, with clearance estimated at 99.9 +/- 2.7% of the actual value.

    Conclusions:

    • Total platinum (TP) pharmacokinetics can be reliably estimated as a clinical alternative to ultrafiltered platinum (UP).
    • The Bayesian approach using limited plasma samples offers accurate TP pharmacokinetic assessment.