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Antimicrobial-resistant pathogens in the 1990s

G A Jacoby1

  • 1Lahey Hitchcock Clinic, Burlington, Massachusetts 01805, USA.

Annual Review of Medicine
|January 1, 1996
PubMed

Insights

Antimicrobial resistance in Streptococcus pneumoniae, Enterococcus, Staphylococcus aureus, and Klebsiella pneumoniae is a growing concern. This review covers resistance epidemiology, detection, mechanisms, and management strategies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Common bacterial pathogens like Streptococcus pneumoniae, Enterococcus species, Staphylococcus aureus, and Klebsiella pneumoniae exhibit increasing resistance to antimicrobial drugs.
  • This rising antimicrobial resistance poses a significant threat to public health and effective treatment of infections.

Purpose of the Study:

  • To provide a comprehensive review of antimicrobial resistance in key bacterial pathogens.
  • To discuss the epidemiology, laboratory detection, resistance mechanisms, and therapeutic options for these resistant bacteria.

Main Methods:

  • Literature review of epidemiology, laboratory diagnostics, and mechanisms of antimicrobial resistance.
  • Analysis of current therapeutic strategies and infection control measures.

Main Results:

  • Detailed overview of the prevalence and spread of antimicrobial resistance in the specified pathogens.
  • Explanation of various laboratory methods for detecting resistance.
  • Elucidation of molecular mechanisms underlying antimicrobial resistance.
  • Summary of effective treatment options and infection control protocols.

Conclusions:

  • Effective management of infections caused by multidrug-resistant bacteria requires a thorough understanding of resistance patterns and mechanisms.
  • Integrated strategies involving diagnostics, therapy, and infection control are crucial to combat the growing threat of antimicrobial resistance.

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