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Updated: Feb 13, 2026

Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response
Published on: December 4, 2013
Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine system
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Abstract:
Nitric oxide is a unique biological messenger molecule. It is produced by endothelial cells to mediate blood vessel relaxation; it mediates, in part, the immune functions of activated macrophages; and in the central and peripheral nervous system it serves as a neurotransmitter. In the nervous system, nitric oxide may regulate neurotransmitter release, it may play a key role in synaptic plasticity and morphogenesis, and it may regulate sexual and aggressive behavior. Under conditions of excessive formation, nitric oxide is emerging as an important neurotoxin.
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