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Related Experiment Videos

Comparative percutaneous absorption of lindane and permethrin

T J Franz1, P A Lehman, S F Franz

  • 1Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, USA.

Archives of Dermatology
|August 1, 1996
PubMed
Summary

5% permethrin cream is a safer alternative to 1% lindane lotion for scabies treatment. Permethrin showed lower absorption and systemic exposure in human and guinea pig skin, reducing neurotoxic risk.

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Area of Science:

  • Dermatology
  • Toxicology
  • Pharmacokinetics

Background:

  • Concerns regarding neurotoxic effects of 1% lindane lotion for scabies treatment.
  • 5% permethrin cream proposed as a safer alternative scabicide.

Purpose of the Study:

  • Compare in vitro percutaneous absorption and in vivo systemic exposure of 5% permethrin cream and 1% lindane lotion.
  • Assess the potential neurotoxic risk associated with these scabicides.

Main Methods:

  • Finite dose technique for in vitro percutaneous absorption studies using human and guinea pig skin.
  • In vivo studies in guinea pigs measuring blood and brain levels after repeated applications.
  • Quantification of permethrin and lindane using gas chromatography/mass spectroscopy.

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Main Results:

  • In vitro absorption was similar in guinea pig skin, but human skin showed 20-fold higher permeability to lindane.
  • In vivo studies revealed fourfold greater lindane levels in guinea pig blood and brain compared to permethrin.
  • Permethrin demonstrated significantly lower systemic exposure.

Conclusions:

  • Systemic exposure and potential neurotoxic risk are substantially lower for 5% permethrin cream compared to 1% lindane lotion.
  • Permethrin is a safer alternative for scabies treatment, especially under conditions of overuse.