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Phosphatidylserine-mediated adhesion of T-cells to endothelial cells
1Department of Cellular Physiology, Babraham Institute, Cambridge, UK.
The Biochemical Journal
|July 15, 1996
Abstract:
Phosphatidylserine was exposed on the surface of human umbilical endothelial cells (ECV304) a few minutes after adding thrombin in vitro, as monitored by prothrombinase assays with and without annexin V. Jurkat T cells adhered to the thrombin-treated cells. The adhesion was inhibited by annexin V, indicating that it was mediated by exposed phosphatidylserine on the endothelial cells.