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Related Experiment Videos

Maternal serum alpha-fetoprotein screening: a cost-benefit analysis

P M Layde, S D von Allmen, G P Oakley

    American Journal of Public Health
    |June 1, 1979
    PubMed
    Summary

    Prenatal screening for neural tube defects (NTD) is cost-effective. This study found that screening 100,000 women for NTD yielded significant economic benefits, exceeding program costs.

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    Minimum fully effective dose of folic acid for the prevention of neural tube defects.

    Epidemiology (Cambridge, Mass.)·2001

    Area of Science:

    • Medical screening programs
    • Public health economics
    • Prenatal diagnostics

    Background:

    • Neural tube defects (NTD) are serious congenital abnormalities.
    • Prenatal detection of NTD is achievable through a multi-tiered screening approach.
    • Maternal serum alpha-fetoprotein (MSAFP) screening is a key component.

    Purpose of the Study:

    • To evaluate the economic consequences of prenatal screening for fetal NTD.
    • To assess the cost-benefit ratio of a comprehensive NTD screening program.
    • To analyze the financial implications for a cohort of at-risk pregnancies.

    Main Methods:

    • Economic analysis of a theoretical cohort of 100,000 pregnant women.
    • Calculation of program costs including screening, ultrasonography, and amniocentesis.
    • Estimation of economic benefits, including averted costs of long-term care and medical interventions.

    Main Results:

    • The total cost for screening 100,000 women was approximately $2,047,780 ($20 per woman).
    • The total economic benefits derived from the program exceeded $4,000,000.
    • The program demonstrated a positive economic return on investment.

    Conclusions:

    • Prenatal screening for fetal NTD is economically advantageous.
    • The benefits of early detection and intervention, including termination of affected pregnancies, outweigh the program's costs.
    • Implementing comprehensive NTD screening programs is financially justifiable.
    Keywords:
    Genetics and Reproduction

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