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The ecology and pathology of Epstein-Barr virus
1Queensland Institute of Medical Research, The Bancroft Centre, Brisbane, Australia.
Immunology and Cell Biology
|December 1, 1995
Abstract:
Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication in epithelial cells. Both of these cell compartments are potential sites for EBV-associated malignancies.