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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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[Exudative uveitis, chronic labial herpes and interstitial pneumonia in an HIV-positive child]

G C Popa1

  • 1Clinica Oftalmologică Craiova.

Oftalmologia (Bucharest, Romania : 1990)
|January 1, 1996
PubMed

Insights

This case study highlights a child with severe growth deficits and ocular issues, confirmed as Human Immunodeficiency Virus (HIV) positive. The findings suggest a link between herpes infections and the observed choroidal lesions in HIV patients.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pediatrics

Background:

  • Human Immunodeficiency Virus (HIV) infection can manifest with various opportunistic infections and ocular complications.
  • Herpes simplex virus (HSV) is a known cause of ocular disease, but its role in HIV-associated choroidal lesions requires further investigation.

Observation:

  • A 6.5-year-old child presented with significant height and weight hypotrophy, ocular abnormalities including pupillary synechiae, vitreous inflammation, and two choroidal exudative plaques in the right eye.
  • Ocular findings included a significant decrease in visual acuity (2/50 uncorrected) and specific lesions: an inter-maculo-papilar plaque and an infero-macular plaque.
  • The child also had a history of chronic labial herpes and interstitial pneumonia, and an ELISA test confirmed HIV positivity.

Findings:

  • The presence of bilateral ocular lesions, specifically exudative choroidal placards, in conjunction with chronic herpes infections and HIV, suggests a potential etiological link.
  • The paper emphasizes the herpetic etiology of the observed choroido-retinal exudative lesions in this pediatric HIV case.

Implications:

  • This case underscores the importance of considering herpetic infections as a cause of choroido-retinal lesions in immunocompromised individuals, particularly pediatric HIV patients.
  • Early diagnosis and appropriate management of both HIV and associated opportunistic infections like herpes are crucial for preventing severe visual impairment and other complications.

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