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Related Experiment Videos

Cell-cell adhesion molecules in epithelial-mesenchymal transformations

A L Prieto1, K L Crossin

  • 1Department of Neurobiology, Scripps Research Institute, La Jolla, Calif. 92037, USA.

Acta Anatomica
|January 1, 1995
PubMed
Summary
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Cell adhesion molecules (CAMs) are crucial for embryonic development, guiding cell collectives during morphogenesis. Their dynamic expression patterns are linked to cell transformations and tissue formation.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • Embryonic development relies on interacting cell collectives, not single cells, to form tissues and organs.
  • Cell adhesion molecules (CAMs) define these cell collectives and their boundaries during morphogenesis.
  • CAM expression is dynamic and changes during epithelial-mesenchymal transformations, influencing morphology.

Purpose of the Study:

  • To review the structure, function, distribution, and gene expression control of CAMs.
  • To discuss the importance of CAMs in normal developmental processes.
  • To highlight the role of CAMs in epithelial-mesenchymal transformations.

Main Methods:

  • Literature review of studies on cell adhesion molecules.
  • Analysis of CAM expression patterns during embryonic development.

Related Experiment Videos

  • Examination of experimental manipulations affecting morphology and CAM expression.

    • Main Results:

    • CAMs play a critical role in organizing cell collectives during embryonic morphogenesis.
    • Changes in CAM expression correlate with alterations in cell morphology.
    • Experimental changes in morphology lead to corresponding changes in CAM expression.

    Conclusions:

    • CAMs are essential regulators of tissue and organ formation in embryos.
    • The dynamic regulation of CAM gene expression is vital for developmental processes, especially epithelial-mesenchymal transformations.