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Systemic responses to SFHS-infusion in hemorrhaged dogs
J Amend1, C Ou, C Ryan-MacFarlane
1Dept. of Physiology, University of Ottawa, ON, Canada.
Summary
Resuscitating hypovolemic dogs with stromafree hemoglobin solution (SFHS) provided adequate hemodynamic and renal recovery but showed early signs of kidney injury compared to whole blood transfusion.
Area of Science:
- Cardiovascular Physiology
- Renal Physiology
- Hemorrhagic Shock Management
Background:
- Hypovolemia significantly impairs hemodynamic and renal function.
- Effective resuscitation strategies are crucial for managing blood loss.
Purpose of the Study:
- To compare the efficacy of unmodified stromafree hemoglobin solution (SFHS) versus autologous whole blood for resuscitation in hypovolemic dogs.
- To assess hemodynamic, renal, and organ-specific blood flow responses to SFHS resuscitation.
Main Methods:
- Mongrel dogs (16-27 Kg) underwent induced hypovolemia (35 ml/Kg blood removal).
- Dogs were resuscitated with either autologous whole blood (Group I) or 6% SFHS (Group II).
- Hemodynamic parameters, organ blood flow, colloid osmotic pressure, and renal function were monitored.
Main Results:
- Both SFHS and whole blood improved cardiac output and renal function.
- SFHS resuscitation led to a transient blood pressure overshoot and bradycardia, with less sustained cardiac output.
- SFHS showed higher N-acetyl-beta-D-glucosaminidase (NAG) excretion, indicating potential renal tubular injury.
Conclusions:
- Unmodified SFHS offers adequate hemodynamic and renal recovery in hypovolemia but may cause early renal tubular injury.
- SFHS resuscitation demonstrates a less sustained hemodynamic response compared to whole blood.
- These findings provide a baseline for evaluating modified hemoglobin solutions.