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Hereditary breast cancer

W Ormiston

    European Journal of Cancer Care
    |March 1, 1996
    PubMed
    Summary

    Genetic discoveries for hereditary breast cancer, including BRCA 1 and BRCA 2 genes, enable predictive testing for women with a family history. Genetic counseling is crucial for informed decisions about screening and risk management.

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    Area of Science:

    • Genetics
    • Oncology
    • Medical Genetics

    Background:

    • Hereditary breast cancer accounts for a significant proportion of all breast cancer cases.
    • Understanding the genetic basis of breast cancer is crucial for risk assessment and management.
    • Recent discoveries have identified key genes associated with hereditary breast cancer.

    Purpose of the Study:

    • To provide an overview of the genetics of hereditary breast cancer.
    • To discuss the clinical aspects and management strategies for this disease.
    • To highlight the implications of recent gene discoveries for patient care.

    Main Methods:

    • Literature review of genetic discoveries and clinical management.
    • Focus on the identification and sequencing of BRCA 1 and BRCA 2 genes.
    • Discussion of the role of genetic testing and counseling.

    Main Results:

    • Identification and sequencing of BRCA 1 (1990) and BRCA 2 (1994) genes.
    • Availability of predictive tests for women with a family history of breast cancer.
    • Recognition of the significant role of genetic factors in breast cancer etiology.

    Conclusions:

    • Genetic discoveries have revolutionized the understanding and management of hereditary breast cancer.
    • Predictive genetic testing offers opportunities for early detection and risk reduction.
    • Genetic nurse specialists are vital in counseling women regarding genetic testing, screening, and risk management.

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