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Related Experiment Videos

The medical dissolution of phytobezoars using cellulase

S P Lee, W D Holloway, G I Nicholson

    The British Journal of Surgery
    |June 1, 1977
    PubMed
    Summary

    Phytobezoars, or stomach masses of plant fiber, can be effectively dissolved using cellulase enzymes. This non-operative treatment is simple, safe, and resolves painful symptoms and serious complications.

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    Area of Science:

    • Gastroenterology
    • Surgical Complications
    • Digestive System Disorders

    Background:

    • Phytobezoars are gastric concretions formed from undigested plant fibers, often occurring after gastric surgery.
    • Symptoms range from distension and pain to severe complications like ulceration, bleeding, and perforation.
    • Untreated phytobezoars carry a significant mortality risk.

    Purpose of the Study:

    • To evaluate the efficacy of non-operative phytobezoar dissolution using enzymes.
    • To assess the safety and simplicity of cellulase-based treatment for phytobezoars.

    Main Methods:

    • Treatment involved the administration of enzymes, specifically cellulase, to break down the phytobezoar mass.
    • The dissolved mass was then either aspirated or passed naturally.
    • Five patients diagnosed with phytobezoars were treated using this method.

    Main Results:

    • The cellulase treatment successfully dissolved phytobezoars in all five patients.
    • The method proved to be simple and safe to administer.
    • No operative intervention was required for successful treatment.

    Conclusions:

    • Enzymatic dissolution, particularly with cellulase, offers an effective non-operative solution for phytobezoars.
    • This approach simplifies management and avoids surgical risks.
    • The cellulase method is a safe and effective treatment option for gastric phytobezoars.

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