[Protamine sulfate reference standard (Control 941) of the National Institute of Health Sciences]

Three kinds of the candidate raw material for protamine sulfate was tested for preparation of the "Protamine Sulfate Reference Standard (Control 941)". The candidates were evaluated by physicochemical tests and anti-heparin tests. Analytical data were summarized in Table 1. Based on the above results, the best one having the highest anti-heparin activity was selected and authorized as the Japanese Pharmacopoeia Reference Standard (Control 941).