Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

Overview
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Operon Model01:23

Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlled-release pheromone dispenser for use in traps to monitor flight activity of false codling moth.

Journal of chemical ecology·2013
Same author

Building the cellular puzzle: control in multi-level reaction networks.

Journal of theoretical biology·2001
Same author

The reversible Hill equation: how to incorporate cooperative enzymes into metabolic models.

Computer applications in the biosciences : CABIOS·1997
Same author

Co-response analysis: a new experimental strategy for metabolic control analysis.

Journal of theoretical biology·1996
Same author

Getting to the inside of cells using metabolic control analysis.

Biophysical chemistry·1994
Same author

Determination of control coefficients in intact metabolic systems.

The Biochemical journal·1994

Related Experiment Video

Updated: Jul 28, 2026

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Metabolic regulation: a control analytic perspective

J H Hofmeyr1

  • 1Department of Biochemistry, University of Stellenbosch, South Africa.

Journal of Bioenergetics and Biomembranes
|October 1, 1995
PubMed
Summary

This study introduces a quantitative theory for metabolic regulation, defining it as altering enzyme properties to manage reaction trends. Elasticity coefficients are key to distinguishing and quantifying regulatory effects in biological systems.

Area of Science:

  • Biochemistry
  • Systems Biology
  • Metabolic Engineering

Background:

  • Metabolic regulation is crucial for cellular function.
  • Existing theories lack a quantitative framework for distinguishing regulatory effects from mass-action trends.

Purpose of the Study:

  • To outline a quantitative theory for metabolic regulation.
  • To define regulatory mechanisms in biological networks.
  • To establish elasticity coefficients as key metrics for quantifying regulation.

Main Methods:

  • Defining metabolic regulation as alteration of reaction properties.
  • Analyzing enzyme-catalyzed reactions using elasticity coefficients.
  • Decomposing elasticity coefficients into mass-action and regulatory kinetic terms.

More Related Videos

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
02:55

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Jul 28, 2026

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
02:55

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue

Published on: October 6, 2023

  • Applying concepts to simple and complex reaction systems.

    • Main Results:

    • Elasticity coefficients quantify metabolic regulation by separating mass-action and regulatory kinetic contributions.
    • These coefficients link metabolic regulation to control, signaling, stability, and homeostasis.
    • Co-response coefficients can measure the elasticity of reaction blocks in complex systems.

    Conclusions:

    • A quantitative framework for metabolic regulation is established.
    • Elasticity coefficients are fundamental for understanding and measuring regulatory processes.
    • The theory provides a basis for analyzing metabolic control in diverse biological systems.