Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic polymorphisms and cancer susceptibility

G Smith1, L A Stanley, E Sim

  • 1Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee.

Cancer Surveys
|January 1, 1995
PubMed
Summary

Most cancers stem from toxic environmental exposures. Genetic variations in drug-metabolizing enzymes like cytochrome P450s, GSTs, and NATs influence susceptibility to carcinogens, impacting cancer risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Who Listens to the Listener, Who Cares for the Carer?' A Cross-Sectional Study of Social Connectedness and Sleep Experiences of Young Siblings of Neurodivergent People.

Child: care, health and development·2024
Same author

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Drug metabolism and disposition: the biological fate of chemicals·2019
Same author

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Drug metabolism and disposition: the biological fate of chemicals·2019
Same author

Human VEGF165-myoblasts produce concomitant angiogenesis/myogenesis in the regenerative heart.

Molecular and cellular biochemistry·2016
Same author

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.

British journal of cancer·2015
Same author

Multivariate assessment of site of lingual nerve.

The British journal of oral & maxillofacial surgery·2015

Area of Science:

  • Environmental toxicology
  • Cancer biology
  • Pharmacogenetics

Background:

  • Environmental agents are primary drivers of cancer.
  • Organisms possess defense mechanisms against toxic exposures.
  • Enzyme induction aids in detoxifying foreign chemicals.

Purpose of the Study:

  • To explore the role of drug-metabolizing enzymes in cancer development.
  • To investigate the impact of genetic polymorphisms in these enzymes on cancer susceptibility.

Main Methods:

  • Review of literature on environmental carcinogens and detoxification pathways.
  • Analysis of genetic polymorphisms in cytochrome P450s, GSTs, and NATs.
  • Correlation of enzyme activity variations with cancer risk.

Main Results:

  • Metabolic activation by enzymes can produce toxic or mutagenic compounds.
  • Altered expression of drug-metabolizing enzymes has significant toxicological implications.
  • Genetic polymorphisms in P450, GST, and NAT genes are linked to varying metabolism of carcinogens.

Conclusions:

  • Genetic variations in drug-metabolizing enzymes influence individual susceptibility to environmentally induced cancers.
  • Polymorphisms can confer protection or increased risk for various tumor types.
  • Understanding these genetic factors is crucial for personalized cancer prevention strategies.

Related Experiment Videos