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Urethritis due to Chlamydia trachomatis

J D Vaughan-Jackson, E M Dunlop, S Darougar

    The British Journal of Venereal Diseases
    |June 1, 1977
    PubMed
    Summary
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    Chlamydia trachomatis is confirmed as a cause of postgonococcal non-specific urethritis (PGU) in men. Ureaplasma urealyticum and Mycoplasma hominis were not found to be pathogenic in the urethra.

    Area of Science:

    • Urology
    • Microbiology
    • Infectious Diseases

    Background:

    • Gonococcal urethritis is a common infection in men.
    • Postgonococcal non-specific urethritis (PGU) can develop after treatment for gonorrhea.
    • The causative agents of PGU are not fully understood.

    Purpose of the Study:

    • To investigate the role of Chlamydia trachomatis and mycoplasmas in the development of PGU.
    • To identify pathogens responsible for non-specific urethritis following gonococcal infection.

    Main Methods:

    • Ninety-five men with gonococcal urethritis were studied.
    • Urethral samples were analyzed for Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis.
    • A control group of 17 men free from PGU was included for comparison.

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  • Serum samples were tested for specific IgM antibodies to Chlamydia trachomatis.

    • Main Results:

    • Chlamydia trachomatis was isolated from 53% of men with PGU, but none of the controls (P < 0.001).
    • Ureaplasma urealyticum was found in 45% of the PGU group and 71% of controls.
    • Mycoplasma hominis was isolated from 20% of the PGU group and 24% of controls.
    • Recent Chlamydia trachomatis infection was suggested by the presence of IgM antibodies in some PGU patients.

    Conclusions:

    • Chlamydia trachomatis is a significant pathogen causing postgonococcal non-specific urethritis.
    • No evidence suggests Ureaplasma urealyticum or Mycoplasma hominis are pathogenic in the male urethra in this context.