Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ion Exchange

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy<sup>⋆</sup>.

Annals of oncology : official journal of the European Society for Medical Oncology·2021

Same author

Profiling of immune-related gene expression in children with familial hypercholesterolaemia.

Journal of internal medicine·2019

Same author

Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.

Molecular immunology·2019

Same author

The role of tumor-derived exosomes in cancer immune evasion mediated by toll-like receptor 4 activation.

Journal of biological regulators and homeostatic agents·2019

Same author

Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Clinical and experimental immunology·2018

Same author

Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Journal of thrombosis and haemostasis : JTH·2018

Search research articles

Related Experiment Video

Updated: Jul 29, 2026

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Alginate polycation microcapsules. II. Some functional properties

B Thu¹, P Bruheim, T Espevik

¹Norwegian Biopolymer Laboratory, Department of Biotechnology, Norwegian Institute of Technology, University of Trondheim, Norway.

|June 1, 1996

Summary

Alginate polycation capsules break due to osmotic swelling. Stabilizing these capsules involves controlling their swelling capacity through material selection and formation kinetics for enhanced chemical and mechanical stability.

More Related Videos

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Related Experiment Videos

Last Updated: Jul 29, 2026

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Area of Science:

Materials Science
Biomaterials Engineering
Chemical Engineering

Background:

Alginate polycation capsules are prone to breakage under physiological conditions.
Osmotic swelling, driven by Donnan equilibrium, is the primary cause of capsule failure.
Stabilizing these capsules is crucial for their practical applications.

Purpose of the Study:

To investigate methods for stabilizing alginate polycation capsules.
To reduce capsule swelling capacity through various strategies.
To enhance the chemical and mechanical stability of alginate polycation capsules.

Main Methods:

Controlling capsule material properties (chemical structure, molecular weight).
Optimizing capsule formation kinetics.
Developing capsules with reduced core swelling capacity.
Utilizing alginate rich in guluronic acid for core and coating.
Implementing anisotropic polymer distribution within the capsule core.

Main Results:

Achieved extensive stabilization of alginate polycation capsules.
Developed capsules with improved chemical and mechanical stability.
Demonstrated effective stabilization by reducing swelling capacity.
Created stable capsules using specific alginate compositions and structural designs.

Conclusions:

Capsule swelling capacity can be effectively controlled to enhance stability.
Material selection and formation kinetics are key parameters for capsule stabilization.
Alginate polycation capsules can be engineered for improved performance and durability.