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Somatostatin

T Reisine1

  • 1Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Cellular and Molecular Neurobiology
|December 1, 1995
PubMed
Summary

Somatostatin (SRIF) regulates physiological functions and is used to treat cancers and acromegaly. Research into its five receptor subtypes advances understanding for new treatments of metabolic diseases, gut disorders, and neurological conditions like epilepsy.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Molecular Biology

Background:

  • Somatostatin (SRIF) regulates hormone release, neurotransmission, and neuronal activity.
  • SRIF analogs are clinically used for cancer treatment and managing acromegaly by blocking growth hormone hypersecretion.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying Somatostatin (SRIF) actions.
  • To identify ligand binding domains and G protein coupling regions of SRIF receptor subtypes.
  • To investigate the role of SRIF in inhibiting cell growth and proliferation.

Main Methods:

  • Cloning of five Somatostatin (SRIF) receptor subtypes.
  • Identification of molecular regions involved in receptor signaling.
  • Generation of subtype-selective SRIF agonists.

Main Results:

  • The molecular basis for Somatostatin (SRIF) cellular actions is being identified.
  • Processes by which Somatostatin (SRIF) inhibits cell growth and proliferation are being established.
  • Subtype-selective agonists are enabling investigation into specific SRIF receptor roles.

Conclusions:

  • Understanding Somatostatin (SRIF) receptor subtypes is crucial for developing novel therapeutics.
  • Future applications include treating metabolic diseases, gastrointestinal disorders, and central nervous system abnormalities.
  • Potential therapeutic targets include epilepsy and Alzheimer's disease.

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