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Ketorolac appears to decrease polyuria during intracranial surgery
1Department of Anesthesiology, St. Louis University Health Sciences Center, MO 63110, USA.
Abstract:
Two cases are described of patients, undergoing surgery for intracranial pathology, who developed polyuria intraoperatively. The urine output decreased to within normal range shortly after the administration of ketorolac, a nonsteroidal antiinflammatory drug. The possible mechanisms producing the increased urinary output and the influence of prostaglandins on renal function are discussed.
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