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Related Experiment Videos

Alterations in cranial morphogenesis in the Lp mutant mouse

D B Wilson1, D P Wyatt

  • 1Division of Anatomy, University of California, San Diego, School of Medicine, La Jolla, USA.

Journal of Craniofacial Genetics and Developmental Biology
|October 1, 1995
PubMed
Summary

Exencephaly in loop-tail mutant mice disrupts cranial development, affecting otocyst position and neuroepithelium integrity. However, some differentiation processes, like roof plate formation, occur independently of neural tube closure.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Neural tube closure is critical for cranial morphogenesis.
  • Defects in neural tube closure, such as exencephaly, can lead to severe developmental abnormalities.

Purpose of the Study:

  • To investigate the impact of exencephaly on cranial development in the loop-tail (Lp) mutant mouse.
  • To determine which aspects of cranial morphogenesis are dependent or independent of neural tube closure.

Main Methods:

  • Studied loop-tail (Lp/Lp) mutant mouse embryos at 10-12 days of gestation.
  • Analyzed hindbrain and spinal cord development, otocyst positioning, and neuroepithelial and mesenchymal differentiation using lectin (WGA, Con A) and anti-N-CAM labeling.

Main Results:

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  • Exencephaly caused ventral displacement of otocysts and altered neuroepithelial lectin binding.
  • Observed presumptive neural crest-like cells at open neural folds.
  • Despite neuroepithelial distortions and loss of integrity, normal roof plate-like neuroepithelium differentiated.
  • Mesenchymal condensations in basicranium and periotic regions appeared normal.

Conclusions:

  • Cranial morphogenesis and differentiation are partially dependent on timely neural tube closure.
  • Some developmental processes, including roof plate formation and mesenchymal condensation, can proceed independently of complete neural tube closure in this model of neural dysraphism.