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Related Experiment Videos

Orthotopic bladder substitutes: histopathologic risk factors

A Nabeeh1, M Gomha, A A Shaaban

  • 1Urology and Nephrology Center, Mansoura, Egypt.

Scandinavian Journal of Urology and Nephrology
|December 1, 1995
PubMed
Summary

Bilharzial bladder cancer can spread to the prostate urethra, especially with basal or multifocal tumors. Routine prostatic biopsies are recommended for patients undergoing bladder substitution surgery to assess risk.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Bilharzial bladder cancer is a significant health concern.
  • Cystoprostatectomy is a common treatment for advanced bladder cancer.
  • Understanding tumor spread is crucial for treatment planning.

Purpose of the Study:

  • To investigate the incidence and patterns of prostatic urethral involvement in patients with bilharzial bladder carcinoma.
  • To identify risk factors for prostatic urethral involvement.
  • To inform surgical decisions regarding bladder substitution.

Main Methods:

  • Histopathological examination of prostate glands from 150 patients undergoing cystoprostatectomy.
  • Step sectioning of prostatic tissue.
  • Correlation of tumor type, location, and invasiveness with prostatic urethral involvement.

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Main Results:

  • Prostatic urethral involvement was observed in 13.5% of squamous cell and 12.5% of transitional cell tumors.
  • Basal and multifocal tumors showed higher rates of urethral involvement (19% and 26.7%) compared to tumors in the bladder body (6.5%).
  • Prostate gland involvement occurred in 13.3% of cases, often associated with basal, infiltrating bladder tumors.

Conclusions:

  • Patients with basal or multifocal bilharzial bladder tumors face a higher risk of prostatic urethral involvement.
  • Routine diagnostic transurethral prostatic biopsies and frozen sections are recommended during cystoprostatectomy for bladder substitution.
  • These measures aid in assessing the risk of urethral involvement and ensuring patient safety.