Growth hormone therapy in Turner syndrome. Analysis of long-term results

The favorable long-term results of growth hormone (GH), alone or in combination with oxandrolone, reported by an American study [J Pediatr 1992; 121:49-55], have so far not been confirmed by other investigators. However, from the presently available data it can be deduced that with higher than substitutive doses of GH, height can be improved during childhood and will be normalized in many patients with Turner syndrome. The future task must be to optimize treatment with respect to the dose and timing of GH (and oxandrolone) in individuals in order to ensure optimal statural outcome at the lowest risk and material costs.