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Related Experiment Videos

Can nonadrenergic inhibitory varicosities be identified structurally

E E Daniel, G S Taylor, V P Daniel

    Canadian Journal of Physiology and Pharmacology
    |April 1, 1977
    PubMed
    Summary

    Axon varicosity vesicle distribution in rabbit jejunum and opossum esophagus suggests no structural difference between cholinergic and non-adrenergic inhibitory axons in vertebrates.

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    Area of Science:

    • Neuroscience
    • Gastrointestinal Physiology
    • Cell Biology

    Background:

    • Intrinsic nerves regulate smooth muscle function via inhibitory junction potentials.
    • Axon varicosities contain vesicles crucial for neurotransmission.
    • Previous studies have explored vesicle types in various neuronal populations.

    Purpose of the Study:

    • To investigate the distribution of vesicles within axon varicosities in the smooth muscle of the rabbit jejunum and opossum esophagus.
    • To correlate vesicle distribution with the observed inhibitory junction potentials.
    • To determine if distinct structural differences exist between cholinergic and non-adrenergic inhibitory axons.

    Main Methods:

    • Microscopic examination of axon varicosities in rabbit jejunum and opossum esophagus.

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  • Stimulation of intrinsic nerves to elicit inhibitory junction potentials.
  • Analysis of vesicle types (large opaque, large dense-cored) within varicosities.

    • Main Results:

    • Circular muscle cells in both species consistently showed inhibitory junction potentials upon nerve stimulation.
    • Inhibitory junction potentials were infrequent in longitudinal muscle cells of the rabbit jejunum.
    • Axon varicosities with a predominance of large vesicles were rare across all examined muscle layers and plexuses, with heterogeneous distribution noted.

    Conclusions:

    • The heterogeneous distribution of vesicles in axon varicosities can explain variations in varicosity morphology.
    • Findings suggest that there is no definitive structural distinction between cholinergic and non-adrenergic inhibitory axons in vertebrates based on vesicle content.