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Related Experiment Videos

Ischemic nephropathy: noninvasive testing

C S Wilcox1

  • 1Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA.

Seminars in Nephrology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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Ischemic nephropathy, caused by renal artery stenosis, requires intervention in select patients. Diagnostic tests are crucial for identifying candidates for procedures like percutaneous transluminal renal angioplasty.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Diagnostic Imaging

Background:

  • Ischemic nephropathy results from renal artery stenosis, leading to hypertension and impaired kidney function.
  • Diagnosis is critical for patients who may benefit from interventions like percutaneous transluminal renal angioplasty (PTRA) or surgery.
  • Work-up is recommended for patients with suggestive hypertension, clinical signs, or significant kidney size disparity.

Purpose of the Study:

  • To outline the diagnostic approach for ischemic nephropathy.
  • To identify appropriate candidates for intervention.
  • To review the utility of various diagnostic tests.

Main Methods:

  • Renal ultrasound to assess kidney size.
  • Tests for overall renal function (creatinine clearance, DTPA plasma disappearance).

Related Experiment Videos

  • Evaluation of functional tests, considering renal insufficiency.
  • Angiotensin-converting enzyme inhibitor (ACEI)-induced renography.
  • Duplex ultrasound scanning of renal arteries.

    • Main Results:

    • Renal ultrasound and functional tests are initial steps for suspected ischemic nephropathy.
    • Diagnostic accuracy of functional tests can be limited by renal insufficiency.
    • ACEI-induced renography may predict reversible renovascular hypertension in renal insufficiency.
    • Duplex ultrasound is accurate for detecting renal artery stenosis.

    Conclusions:

    • A systematic approach is necessary for diagnosing ischemic nephropathy and selecting patients for intervention.
    • Further research is needed to quantify the predictive value of noninvasive tests for functional improvement post-intervention.