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Related Experiment Videos

Immunomorphological lymph node changes in patients with operable bronchogenic squamous cell carcinoma

M Kaufmann, K Wirth, J Scheurer

    Cancer
    |June 1, 1977
    PubMed
    Summary

    Lymph node structure in lung cancer patients reveals immune response indicators linked to survival. Histometric analysis of lymph nodes can identify high-risk individuals with bronchogenic squamous cell carcinoma.

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    Area of Science:

    • Oncology
    • Immunology
    • Pathology

    Background:

    • Bronchogenic squamous cell carcinoma is a significant cause of cancer mortality.
    • Prognostic indicators are crucial for tailoring treatment and identifying high-risk patients.
    • Lymph node status is a key factor in cancer staging and patient outcomes.

    Purpose of the Study:

    • To investigate the correlation between histological changes in lymph nodes and patient survival in operable lung cancer.
    • To identify specific immune response parameters within lymph nodes that predict prognosis.
    • To explore the utility of quantitative histometry in assessing lymph node immune status.

    Main Methods:

    • Histometric analysis of tracheobronchial and bronchopulmonary lymph nodes from 29 patients with operable lung cancer.

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  • Quantitative measurement of cellular and humoral immune response parameters, including lymphoid cell counts, mitotic figures, and follicular/germinal center volumes.
  • Correlation of measured parameters with patient survival data (less than 12 months vs. greater than 2 years).

    • Main Results:

    • Relative numbers of large lymphoid cells and mitotic figures in the paracortical area correlated with survival.
    • Volume of the follicular cortex and germinal centers showed a correlation with patient survival.
    • Accumulation of histiocytes/macrophages and absence of sinuhistiocytosis in lymph sinusoids inversely correlated with survival.

    Conclusions:

    • Lymph node immune response parameters, assessed quantitatively, are significant prognostic indicators in lung cancer.
    • Histometric analysis of lymph nodes can aid in identifying high-risk patient groups within the same cancer stage.
    • These findings contribute to understanding the immune microenvironment's role in lung cancer progression and survival.