Related Experiment Video

Updated: Aug 27, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
08:30

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

Cardiac transplantation in patients aged 60 years or older

L Mischke1, S Sisson, D K Cooper

  • 1Oklahoma Transplantation Institute, Baptist Medical Center of Oklahoma, Oklahoma City 73112, USA.

The Journal of the Oklahoma State Medical Association
|January 1, 1996
PubMed

Insights

Older heart transplant recipients (60+) demonstrated comparable survival rates to younger patients, suggesting careful evaluation and post-transplant care are key for successful outcomes in this age group.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Geriatric Medicine

Background:

  • Heart transplantation is a critical treatment for end-stage heart failure.
  • Patient age is a significant factor influencing transplant outcomes.
  • Previous studies indicate poorer survival for older heart transplant recipients.

Purpose of the Study:

  • To evaluate the outcomes of heart transplantation in patients aged 60 years or older compared to younger recipients.
  • To identify factors contributing to survival rates in older heart transplant recipients.

Main Methods:

  • Retrospective review of 184 consecutive heart transplant patients from January 1987 to December 1994.
  • Patients were divided into two groups: Group A (≥60 years, n=50) and Group B (<60 years, n=134).
  • Survival rates were analyzed at 1, 5, and 8 years post-transplantation.

Main Results:

  • Patients aged 60 and older showed improved, though not statistically significant, overall survival compared to younger patients.
  • One-year survival: 94% (Group A) vs. 90% (Group B).
  • Five-year survival: 86% (Group A) vs. 80% (Group B).
  • Eight-year survival: 86% (Group A) vs. 78% (Group B).

Conclusions:

  • Older heart transplant recipients at this center achieved favorable survival rates.
  • Thorough pre-transplant evaluation and enhanced post-transplant compliance may contribute to positive outcomes in older adults.
  • Findings challenge the general trend of inferior survival for older patients in heart transplantation globally.

More Related Videos

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...