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Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function
C Eftimiadi1, S Valente, S Mangiante
1Department of Periodontology, Harvard School of Dental Medicine, Boston, MA, USA.
Minerva Stomatologica
|October 1, 1995
Abstract:
The effect on B-lymphocytes of butyric acid, a metabolic by-product formed by selected anaerobic bacteria of the subgingival plaque and present in mM amounts in the crevicular fluid of patients affected by adult periodontitis was investigated. A dose-dependent inhibition of both mitogenesis and Ig production in B-cells challenged with formalinized Staphylococcus aureus, strain Cowan I (SAC), was observed. A role of this molecule in the downregulation of the local immune response in periodontal patients is proposed.