Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetics and molecular detoxication

J R Cashman1, B Y Perotti, C E Berkman

  • 1Seattle Biomedical Research Institute, Washington 98109, USA.

Environmental Health Perspectives
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of glutamate carboxypeptidase II by phosphonamidothionate derivatives of glutamic acid.

Journal of enzyme inhibition·2002
Same author

Stereoselective inhibition of glutamate carboxypeptidase by chiral phosphonothioic acids.

Bioorganic & medicinal chemistry·2001
Same author

Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.

Oncogene·2000
Same author

[Insulin-like growth factor system in human ovary and its actions].

Zhonghua yi xue za zhi·2000
Same author

[The effect of amlodipine, nifedipine and perindopril on insulin sensitivity and blood lipid of patients with essential hypertension].

Zhonghua yi xue za zhi·2000
Same author

Protein folds in the worm genome.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2000

This study explores toxicokinetics and environmental chemical disposition using pharmacokinetic parameters from in vivo and in vitro studies. It highlights the value of in vitro data for predicting human health risks from toxicant exposure.

Area of Science:

  • Environmental Toxicology
  • Pharmacokinetics
  • Biochemistry

Background:

  • Understanding the disposition of environmental chemicals is crucial for risk assessment.
  • Toxicokinetics integrates pharmacokinetic principles to study chemical toxicity.
  • In vitro and in vivo studies provide essential data for toxicological evaluations.

Purpose of the Study:

  • To provide a comprehensive overview of pharmacokinetic parameters in toxicokinetics.
  • To emphasize the utility of in vitro data for in vivo correlations.
  • To illustrate interspecies scaling for metabolic processes and risk assessment.

Main Methods:

  • Review of in vivo and in vitro pharmacokinetic studies.
  • Analysis of biochemical data on environmental chemical detoxification.

Related Experiment Videos

  • Examination of interspecies scaling principles and applications.
  • Presentation of key metabolic detoxication enzymes (e.g., cytochrome P450).

    • Main Results:

    • In vitro measurements can be reliably correlated with in vivo outcomes.
    • Interspecies scaling aids in extrapolating metabolic data across species.
    • Pharmacokinetic equations are valuable tools for toxicological assessments.
    • Key enzymes involved in chemical detoxification are identified.

    Conclusions:

    • Pharmacokinetic approaches, particularly in vitro-in vivo correlations, enhance understanding of chemical disposition.
    • This framework supports the evaluation of human health risks from environmental toxicants.
    • Confidence in using pharmacokinetic models for risk assessment is increased.