Helicobacter pylori and dyspepsia

Non-ulcer dyspepsia (NUD) is a common condition that often goes unrecognized. Although approximately 50% of patients with NUD are infected with Helicobacter pylori, attempts to establish a link between this organism and the pathogenesis of NUD have yielded conflicting results. Recent studies have shown that eradication of H. pylori leads to improvements in symptoms in patients with NUD, and have highlighted the importance of long-term follow-up in this condition. It is possible that patients with NUD and H. pylori infection have a discrete condition that forms part of a spectrum of peptic ulcer disease. Hence, it may soon be possible to recommend H. pylori eradication treatment for patients with NUD.