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Comparative distribution of resistance patterns and serotypes in Pseudomonas aeruginosa isolates from intensive care
1Service de Microbiologie, Hôpital Beaujon, Clichy, France.
Abstract:
The resistance patterns and O-serotypes of 2952 Pseudomonas aeruginosa isolates were studied and the relationship between patterns and serotypes was investigated. The penicillinase-producing and cephalosporinase-overproducing phenotypes were significantly more frequent in intensive care units than other wards, but there was no difference for the intrinsic resistance phenotype. The predominant serotypes were O6, O11 and O1. The incidence of serotype O12 was low. O11 isolates were more common in intensive care units and more resistant to all antibiotics than other isolates. Most O12 isolates had a penicillinase-producing phenotype and were resistant to aminoglycosides and ciprofloxacin, but susceptible to fosfomycin.
Insights
This study investigated Pseudomonas aeruginosa resistance patterns and O-serotypes. Intensive care unit isolates, particularly O11, showed higher resistance, while O12 isolates exhibited specific resistance profiles.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Science
Background:
- Pseudomonas aeruginosa is a significant opportunistic pathogen.
- Understanding its resistance patterns and serotypes is crucial for effective treatment.
Purpose of the Study:
- To investigate the relationship between O-serotypes and antibiotic resistance patterns of Pseudomonas aeruginosa.
- To identify prevalent serotypes and their distribution in different hospital wards.
Main Methods:
- Analysis of 2952 Pseudomonas aeruginosa isolates.
- Characterization of O-serotypes and antibiotic resistance phenotypes.
- Comparison of resistance patterns between intensive care units and other wards.
Main Results:
- Penicillinase-producing and cephalosporinase-overproducing phenotypes were more frequent in intensive care units.
- Serotypes O6, O11, and O1 were predominant.
- Serotype O11 isolates showed increased resistance to all antibiotics and were more common in ICUs.
- Serotype O12 isolates were less common, often penicillinase-producing, and resistant to aminoglycosides and ciprofloxacin but susceptible to fosfomycin.
Conclusions:
- Specific O-serotypes of Pseudomonas aeruginosa are associated with distinct antibiotic resistance profiles.
- Serotype O11 is a significant concern in intensive care units due to its high resistance.
- Serotype O12 presents a unique resistance pattern that may inform targeted therapy.