Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations

E R Hauser1, M Boehnke, S W Guo

  • 1Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109-2029, USA.

Genetic Epidemiology
|January 1, 1996
PubMed
Summary

This study extends Risch's linkage analysis method for complex traits using affected sib pairs (ASPs). It proposes efficient genome screening strategies to identify disease gene regions and prioritize further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Research on the evaluation of the automatic construction effectiveness of a flexible point cloud deformation algorithm for nasal prostheses].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same author

[Analysis of adjuvant chemotherapy efficacy based on GLUT1 expression levels after radical resection of pancreatic cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Study on the consistency between the trajectory of small opening and closing movements and the empirical hinge axis movement of the mandibular incisal point of healthy individuals].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same author

No association between genetic ancestry and exome sequencing-based diagnosis of inborn errors of metabolism.

NPJ genomic medicine·2026
Same author

[Clinical value of secondary surgical resection for recurrent or metastatic pancreatic cancer after initial surgery].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change.

medRxiv : the preprint server for health sciences·2024

Area of Science:

  • Genetics
  • Statistical Genetics
  • Bioinformatics

Background:

  • Complex genetic traits pose challenges for linkage analysis.
  • Risch's method provides a framework for linkage detection and exclusion.

Purpose of the Study:

  • To extend Risch's method for complex traits using affected sib pairs (ASPs).
  • To develop efficient genome screening tools for prioritizing genomic regions.
  • To optimize study design for linkage analysis.

Main Methods:

  • Interval mapping to infer identity-by-descent (IBD) sharing in ASPs.
  • Likelihood-based analysis using recurrence risk ratios.
  • Development of linkage detection and exclusion tests.

Main Results:

Related Experiment Videos

  • Proposed a genome screening strategy using a large panel of ASPs and evenly spaced genetic markers.
  • Recommended investigating regions with lod scores > 1 and excluding regions with lod scores < -2.
  • Demonstrated efficiency in genotyping and focus on regions with substantial disease gene impact.

Conclusions:

  • The extended method and screening strategy are efficient for identifying disease gene regions.
  • The approach balances the number of genotypings with the pursuit of significant linkage signals.
  • Optimal study design involves initial typing of ASPs with a specific marker map.