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Bone and joint infections in patients with infective endocarditis: review of a 4-year experience

F L Sapico1, J A Liquete, R J Sarma

  • 1Department of Medicine, University of Southern California School of Medicine, Los Angeles, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|May 1, 1996
PubMed

Insights

Infective endocarditis (IE) can present with musculoskeletal complaints. Osteoarticular infection (OAI) is common in intravenous drug abusers (IVDAs) with IE, but rare in non-IVDAs.

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Cardiology

Background:

  • Musculoskeletal complaints are frequently reported in patients with infective endocarditis (IE).
  • The association between IE and osteoarticular infections (OAI) requires further investigation, particularly concerning risk factors.

Purpose of the Study:

  • To determine the incidence and characteristics of osteoarticular infections (OAI) in patients with infective endocarditis (IE).
  • To investigate the correlation between intravenous drug abuse (IVDA) and the occurrence of OAI in IE patients.

Main Methods:

  • Retrospective review of 104 infective endocarditis (IE) cases over 4 years.
  • Analysis of patient data to identify initial symptoms, documented infections, and patient demographics, including intravenous drug abuse (IVDA) status.

Main Results:

  • 23% of IE cases began with musculoskeletal complaints.
  • Osteoarticular infection (OAI) was documented in 15% of all IE cases, predominantly in intravenous drug abusers (IVDAs).
  • OAI was absent in non-IVDA IE patients, and typically involved single bone or joint sites in IVDAs.

Conclusions:

  • Osteoarticular infection (OAI) is significantly more common in intravenous drug abusers (IVDAs) with infective endocarditis (IE).
  • Musculoskeletal complaints in IVDA patients with IE warrant a thorough investigation for OAI.
  • OAI appears to be an uncommon complication of IE in non-IVDA individuals.

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