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The C19-mineralocorticoids in hypertension

J A Sennett, L R Yarbro, P E Slaton

    Circulation Research
    |August 1, 1977
    PubMed
    Summary

    C19-mineralocorticoid excretion was measured in patients with low-renin essential hypertension and toxemia of pregnancy. The study found these steroids likely do not play a significant role in either condition.

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    Area of Science:

    • Endocrinology
    • Nephrology
    • Obstetrics

    Background:

    • C19-mineralocorticoids, specifically 16beta-hydroxy-DHEA and 16-oxo-androstenediol, are endogenous steroids.
    • Their role in conditions like low-renin essential hypertension and toxemia of pregnancy requires further investigation.

    Purpose of the Study:

    • To quantify the excretion rates of 16beta-hydroxy-DHEA and 16-oxo-androstenediol in individuals with low-renin essential hypertension and toxemia of pregnancy.
    • To determine if these C19-mineralocorticoids are implicated in the pathophysiology of these conditions.

    Main Methods:

    • Measurement of urinary excretion rates of 16beta-hydroxy-DHEA and 16-oxo-androstenediol.
    • Comparison of excretion levels between patient groups (low-renin essential hypertension, toxemia of pregnancy) and normal controls.

    Main Results:

    • Excretion rates of C19-mineralocorticoids in low-renin essential hypertension ranged from 70-790 microgram/day.
    • No significant difference in 16beta-hydroxy-DHEA and 16-oxo-androstenediol excretion was observed between patients with low-renin essential hypertension and normal controls.
    • Subjects with toxemia of pregnancy excreted 350-2500 microgram/day of these steroids, with no significant difference compared to normal pregnancy.

    Conclusions:

    • The excretion patterns of 16beta-hydroxy-DHEA and 16-oxo-androstenediol do not significantly differ between patients with low-renin essential hypertension and healthy individuals.
    • Similarly, no significant differences were found in the excretion of these steroids during toxemia of pregnancy compared to normal pregnancy.
    • These findings suggest that 16beta-hydroxy-DHEA and 16-oxo-androstenediol are unlikely to play a major role in the pathogenesis of low-renin essential hypertension or toxemia of pregnancy.

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