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Abnormal modulation of cholinergic neurotransmission by opioid in hyperresponsive bronchus of rats
1Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
General Pharmacology
|April 1, 1996
Abstract:
1. The electrical field stimulation (EFS)-induced bronchoconstriction in vitro in rats challenged by DNP-Ascaris antigen was significantly greater than that in normal rats. 2. Morphine inhibited the EFS-induced bronchoconstriction in normal rats. Whereas the inhibition of EFS-induced bronchoconstriction by the opioid was little, if any, in the DNP-Ascaris-challenged rats. 3. These findings suggest that dysfunction of presynaptic inhibitory modulation through the opioid receptor may take place in the airways of DNP-Ascaris-challenged rats.