Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The general principles of cellular gravisensing]

M G Tairbekov

    Izvestiia Akademii Nauk. Seriia Biologicheskaia
    |March 1, 1996
    PubMed
    Summary

    This review reveals common molecular pathways for cell gravisensing across diverse cell types adapting to altered gravity. A unified mechanism for how cells sense gravity has been identified.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Cell biology researches aboard the robotic space vehicles: preparation and performance].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2007
    Same author

    [Experiments in fundamental biology in flight of space apparatus Foton-M2].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2006
    Same author

    [Problems of exobiology: the origin of life on Earth].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2004
    Same author

    Cytogenetic characteristic of osteogenic cells in vitro as perspective predictors of osteopenia under microgravity.

    Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2003
    Same author

    [Evolution of the interaction fo living systems with the environment].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2002
    Same author

    Probable mechanisms of the gravitational sensitivity of cells.

    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2001

    Area of Science:

    • Cell Biology
    • Gravitational Biology
    • Spaceflight Research

    Background:

    • Cellular responses to gravity are crucial for understanding life in altered gravitational environments.
    • Decades of research have explored how different cell types perceive and react to gravity.
    • Previous studies utilized clinostats, centrifuges, and spaceflight to simulate altered gravity conditions.

    Purpose of the Study:

    • To review and synthesize long-term research on cellular mechanisms of gravireception.
    • To identify commonalities and differences in cell adaptation to altered gravity.
    • To elucidate an integral molecular mechanism for cell gravisensing.

    Main Methods:

    • Review of author's laboratory studies on cellular mechanisms of gravireception.
    • Experimental simulation of altered gravity using clinostats and centrifuges.
    • Analysis of data from spaceflight experiments.
    • Comparative analysis with existing published data.

    Main Results:

    • Identified specific adaptation features for different cell types under altered gravity, including microgravity.
    • Revealed common pathways in the structural-functional adaptation of cells to altered gravity.
    • Uncovered an integral molecular mechanism underlying cellular gravisensing.

    Conclusions:

    • Despite cell-type specific adaptations, common molecular pathways govern cellular responses to gravity.
    • A unified model for cell gravisensing has been proposed.
    • This work formulates a working hypothesis on the general principles of cell gravisensing.

    Related Experiment Videos