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Ketorolac does not decrease postoperative pain in elderly men after transvesical prostatectomy

B Fredman1, D Olsfanger, P Flor

  • 1Department of Anesthesiology and Critical Care, Meir Hospital, Kfar Sava, Israel.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|May 1, 1996
PubMed
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Ketorolac did not improve postoperative pain relief or reduce morphine use in elderly men after prostate surgery. This study found no analgesic benefit from ketorolac in this patient group.

Area of Science:

  • Anesthesiology
  • Geriatric Medicine
  • Pharmacology

Background:

  • Postoperative pain management is crucial, especially in elderly patients.
  • Non-opioid analgesics are sought to reduce opioid-related side effects.
  • Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties.

Purpose of the Study:

  • To evaluate the effectiveness of ketorolac in managing postoperative pain.
  • To determine if ketorolac can reduce the need for morphine (morphine-sparing effect).
  • To assess these effects specifically in elderly male patients undergoing prostatectomy.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Sixty elderly male patients (60-88 years) undergoing transvesical prostatectomy were included.

Related Experiment Videos

  • Patients received either ketorolac (60 mg IM) or saline placebo before surgery completion, with pain assessed via VAS and PCA.

    • Main Results:

    • There were no significant differences in patient-controlled analgesia (PCA) demands between groups.
    • Actual morphine consumption was similar in both the ketorolac and placebo groups (10.8 mg vs. 11.9 mg).
    • Patient-reported pain scores (Visual Analog Scale - VAS) were not improved by ketorolac administration.

    Conclusions:

    • Intraoperative administration of ketorolac (60 mg IM) did not provide postoperative analgesia in elderly men.
    • Ketorolac did not demonstrate a morphine-sparing effect in this study population.
    • The use of ketorolac in this context did not enhance pain management outcomes.