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Related Experiment Videos

Chronic idiopathic constipation: pathophysiology and treatment

P Velio1, G Bassotti

  • 1Cattedra di Gastroenterologia, Università degli Studi di Milano, IRCSS-Ospedale Maggiore di Milano, Italy.

Journal of Clinical Gastroenterology
|April 1, 1996
PubMed
Summary

Chronic constipation, particularly idiopathic constipation, affects many, especially women. Treatment ranges from lifestyle changes to surgery for severe cases.

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Area of Science:

  • Gastroenterology
  • Digestive Health

Background:

  • Chronic constipation is a prevalent condition, disproportionately affecting women.
  • Idiopathic constipation lacks a universally standardized definition, causing diagnostic challenges.
  • Constipation is broadly classified into normal transit and slow transit subtypes with distinct, incompletely understood pathophysiology.

Purpose of the Study:

  • To clarify the definition and classification of chronic constipation.
  • To outline the spectrum of therapeutic interventions for constipation.
  • To identify patient subgroups requiring advanced treatment modalities.

Main Methods:

  • Literature review of existing definitions and classifications.
  • Analysis of pathophysiological differences between normal and slow transit constipation.

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  • Review of treatment strategies, from conservative to surgical.

    • Main Results:

    • Despite standardization efforts, constipation definition remains debated.
    • Normal transit and slow transit constipation represent distinct pathophysiological entities.
    • A stepwise approach to treatment is effective for most patients.

    Conclusions:

    • Effective management of chronic constipation involves lifestyle adjustments, pharmacotherapy, and potentially psychological interventions.
    • Surgical options exist for a small subset of patients with intractable constipation.
    • Further research is needed to fully elucidate the pathophysiology of different constipation subtypes.