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Related Experiment Videos

Antibiotic-associated colitis

R R Miller, H Jick

    Clinical Pharmacology and Therapeutics
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Antibiotic-associated colitis is rare in hospitalized patients, but can occur in outpatients. This study found seven outpatient cases, primarily linked to lincomycin, highlighting a rare but serious adverse drug event.

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    Area of Science:

    • Pharmacovigilance
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Antibiotics are widely used, but can cause adverse drug reactions.
    • Drug-induced colitis is a known, though infrequent, complication of antibiotic therapy.
    • Hospitalized patients in the Boston Collaborative Drug Surveillance Program (BCDSP) showed no cases of in-hospital antibiotic-induced colitis.

    Purpose of the Study:

    • To investigate the incidence and characteristics of antibiotic-associated colitis.
    • To identify specific antibiotics linked to colitis in outpatient settings.

    Main Methods:

    • Retrospective review of hospitalized patients within the BCDSP.
    • Analysis of cases presenting with antibiotic-associated colitis, focusing on prior antibiotic exposure.

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  • Case series of seven outpatients diagnosed with antibiotic-associated colitis.

    • Main Results:

    • No cases of antibiotic-induced colitis were diagnosed among 26,294 hospitalized patients receiving antibiotics.
    • Seven outpatients were admitted with antibiotic-associated colitis.
    • Six of these seven patients had taken lincomycin; one had taken ampicillin.
    • Five lincomycin cases occurred within an 11-month period at a New Zealand hospital.

    Conclusions:

    • Antibiotic-associated colitis is a rare event, particularly in hospitalized patients in the US.
    • Outpatient antibiotic use, especially lincomycin, may be associated with a risk of developing colitis.
    • Further surveillance may be needed to fully understand the risk of antibiotic-associated colitis in outpatient settings.