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Related Experiment Videos

Lithium carbonate and methyldopa: apparent interaction in man

G J Byrd

    Clinical Toxicology
    |January 1, 1977
    PubMed
    Summary

    Concurrent use of lithium and methyldopa may lead to lithium toxicity. This drug interaction necessitates caution for physicians prescribing these medications to patients, especially those with stable lithium levels.

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    Area of Science:

    • Pharmacology
    • Clinical Toxicology

    Background:

    • Lithium is a common mood stabilizer.
    • Methyldopa is an antihypertensive medication.

    Purpose of the Study:

    • To report a potential drug interaction between lithium and methyldopa.

    Main Methods:

    • Case report of a single experimental subject.

    Main Results:

    • A subject with stable serum lithium levels developed lithium toxicity after ingesting methyldopa.

    Conclusions:

    • An apparent interaction between lithium and methyldopa can precipitate lithium toxicity.
    • Clinicians should be aware of this interaction when prescribing lithium and/or methyldopa.